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A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratioMay 16 2019Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a mechanism ... More
Anomalous Advection-Diffusion Models for Avascular Tumour GrowthMay 14 2019In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour spheroid. This understanding ... More
Supervised machine learning based multi-task artificial intelligence classification of retinopathiesMay 10 2019Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly ... More
Surface tension controls the onset of gyrification in brain organoidsMay 09 2019Understanding the mechanics of brain embryogenesis can provide insights on pathologies related to brain development, such as lissencephaly, a genetic disease which cause a reduction of the number of cerebral sulci. Recent experiments on brain organoids ... More
Comparative approaches to understanding thyroid hormone regulation of neurogenesisMay 09 2019Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development, increasing ... More
Mechanical heterogeneity in tissues promotes rigidity and controls cellular invasionMay 07 2019We study the influence of cell-level mechanical heterogeneity in epithelial tissues using a vertex-based model. Heterogeneity in single cell stiffness is introduced as a quenched random variable in the preferred shape index($p_0$) for each cell. We uncovered ... More
Tuning the Transdermal Transport by Application of External Continuous Electric Field: A Molecular Dynamics Coarse-Grained StudyMay 06 2019Since a long time the application of small electric potentials on biological membranes (iontophoresis) proved enabling control and improvement of transdermal delivery of substances across this barrier. In spite of a large experimental data, the detailed ... More
Machine Learning to Predict Developmental Neurotoxicity with High-throughput Data from 2D Bio-engineered TissuesMay 06 2019There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from ... More
Glassy Dynamics in Models of Confluent Tissue with Mitosis and ApoptosisMay 05 2019Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy dynamics in ... More
Paper-based cell cryopreservationMay 02 2019The continuous development of simple and practical cell cryopreservation methods is of great importance to a variety of sectors, especially when considering the efficient short- and long-term storage of cells and their transportation. Although the overall ... More
An orthotropic electro-viscoelastic model for the heart with stress-assisted diffusionMay 01 2019May 20 2019We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law (this is so for ... More
An orthotropic electro-viscoelastic model for the heart with stress-assisted diffusionMay 01 2019We propose and analyse the properties of a new class of models for the electromechanics of the cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law (this is so ... More
Energy Balance in Cell Phone Radiofrequency Radiation Exposed Mice and RatsApr 29 2019The National Toxicology Program exposed mice and rats to cell phone radiofrequency radiation. They observer cancers in male rats but not in male mice and different increases in body temperature between mice and rats using identical frequency and intensity ... More
A mechanism for sarcomere breathing: volume changes and advective flow within the myofilament latticeApr 29 2019During muscle contraction, myosin motors anchored on thick filaments bind to and slide actin thin filaments. These motors rely on ATP, supplied at the limits of diffusion from the sarcoplasm to the interior of the lattice of actin and myosin. Classic ... More
Voluntary phantom hand and finger movements in transhumeral amputees could be used to naturally control polydigital prosthesesApr 26 2019An arm amputation is extremely invalidating since many of our daily tasks require bi-manual and precise control of hand movements. Perfect hand prostheses should therefore offer a natural, intuitive and cognitively simple control over their numerous biomimetic ... More
Can fallopian tube anatomy predict pregnancy and pregnancy outcomes after tubal reversal surgery?Apr 21 2019We conducted this study to determine if postoperative fallopian tube anatomy can predict the likelihood of pregnancy and pregnancy outcomes after tubal sterilisation reversal. We built a flexible, non-parametric, multivariate model via generalised additive ... More
Quantification of Nematic Cell Polarity in Three-dimensional TissuesApr 18 2019How epithelial cells coordinate their polarity to form complex tissues and organs remains a fundamental question in biology. Here, we characterize a unique type of polarity found in liver tissue - nematic cell polarity, which is different from the common ... More
Impaired coronary blood flow at higher heart rates during atrial fibrillation: investigation via multiscale modellingApr 16 2019Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the present work ... More
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary reportApr 12 2019Psychosocial stress during pregnancy is a known contributor to preterm birth, but also has been increasingly appreciated as an in utero insult acting long-term on prenatal and postnatal neurodevelopmental trajectories. These events impact many information ... More
Interpretable Classification from Skin Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter StudyApr 12 2019For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep convolutional neural networks ... More
DNN-based Acoustic-to-Articulatory Inversion using Ultrasound Tongue ImagingApr 12 2019Speech sounds are produced as the coordinated movement of the speaking organs. There are several available methods to model the relation of articulatory movements and the resulting speech signal. The reverse problem is often called as acoustic-to-articulatory ... More
Conformational catalysis of cataract-associated aggregation by interacting intermediates in a human eye lens crystallinApr 07 2019Most known proteins in nature consist of multiple domains. Interactions between domains may lead to unexpected folding and misfolding phenomena. This study of human {\gamma}D-crystallin, a two-domain protein in the eye lens, revealed one such surprise: ... More
Electric-induced reversal of morphogenesis in Hydra regenerationApr 07 2019Morphogenesis in whole-body regeneration requires the dynamic interplay of three types of processes: biochemical, mechanical and electrical, which span all scales from the molecular to the entire organism. Despite significant progress in elucidating the ... More
Cell damage and mitigation in Swiss albino mice: experiment and modellingApr 05 2019Chronic exposure to inorganic arsenic is a potential cause of carcinogenesis. It elicits its potential by generation of ROS, leading to DNA, protein and lipid damage. Therefore, the deleterious effect of arsenic can be mitigated by quenching ROS using ... More
Respiratory sympathetic modulation is augmented in chronic kidney diseaseApr 03 2019Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions ... More
Passive Cervical Spine Ligaments Provide Stability during Head Impacts in VivoApr 02 2019It has long been suggested that neck muscle strength and anticipatory cocontraction can decrease head motions during head impacts. Here, we quantify the relative angular impulse contributions of neck soft tissue to head stabilization using a musculoskeletal ... More
Alternative Scoring Method of Pleurisy in Slaughtered Pigs: Preliminary InvestigationsApr 02 2019The slaughterhouse is very useful in monitoring the health status of livestock, the profitability of their breeding and the effectiveness of therapeutic and/or prophylactic strategies. Over the years, a number of methods have been developed to quantify ... More
Quantitative phase microscopy spatial signatures of cancer cellsApr 02 2019We present cytometric classification of live healthy and cancer cells by using the spatial morphological and textural information found in the label-free quantitative phase images of the cells. We compare both healthy cells to primary tumor cell and primary ... More
The Configuration of the Perivascular System Transporting Macromolecules in the CNS (PREPRINT)Apr 02 2019Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space. Solutes and particles can translocate along these perivascular conduits, reportedly ... More
A Deterministic Method to Calculate the AIS Trauma Score from a Finite Element Organ Trauma Model (OTM)Apr 01 2019Traumatic injuries are measured using the Abbreviated Injury Scale (AIS), which is a risk to life scale. New human computer models use stresses and strains to evaluate whether serious or fatal injuries are reached, unfortunately these tensors bear no ... More
Overt and covert paths for sound in the auditory system of mammalsMar 28 2019Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we propose a bioelectronic ... More
Deciphering the underlying mechanisms of the pharyngeal motions in Caenorhabditis elegansMar 28 2019The pharynx of the nematode Caenorhabditis elegans is a neuromuscular pump that exhibits two typical motions: pumping and peristalsis. While the dynamics of these motions are well characterized, the underlying mechanisms generating most of them are not ... More
Effect of MTU length on child-adult difference in neuromuscular fatigueMar 27 2019Purpose The purpose of this study was to compare the development and etiology of neuromuscular fatigue of the knee extensor muscles (KE) at different muscle-tendon unit (MTU) lengths during repeated maximal voluntary isometric contractions (MVIC) between ... More
Single-cell approaches to cell competition: high-throughput imaging, machine learning and simulationsMar 25 2019Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been identified in many physiological and pathological contexts, driven either by ... More
A quantitative study on the role of TKI combined with Wnt/$β$-catenin signaling and IFN-$α$ in the treatment of CML through deterministic and stochastic approachesMar 22 2019We propose deterministic and stochastic models for studying the pharmacokinetics of chronic myeloid leukemia (CML), upon administration of IFN-$\alpha$ (the traditional treatment for CML), TKI (the current frontline medication for CML) and Wnt/$\beta$-catenin ... More
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine IL-6 are related to synovitis and pain in end-stage knee osteoarthritis patientsMar 20 2019Little is known about local and systemic biomarkers in relation to synovitis and pain in end-stage osteoarthritis (OA) patients. We investigated the associations between the novel extracellular matrix biomarker, C1M, and local and systemic interleukin ... More
From individual-based mechanical models of multicellular systems to free-boundary problemsMar 15 2019In this paper we present an individual-based mechanical model that describes the dynamics of two contiguous cell populations with different proliferative and mechanical characteristics. An off-lattice modelling approach is considered whereby: (i) every ... More
Interkinetic nuclear migration in the zebrafish retina as a diffusive processMar 13 2019A major hallmark of neural development is the oscillatory movement of nuclei between the apical and basal surfaces of the neuroepithelium during the process of interkinetic nuclear migration (IKNM). Here, we employ long-term, rapid lightsheet and two-photon ... More
Towards Unsupervised Cancer Subtyping: Predicting Prognosis Using A Histologic Visual DictionaryMar 12 2019Unlike common cancers, such as those of the prostate and breast, tumor grading in rare cancers is difficult and largely undefined because of small sample sizes, the sheer volume of time needed to undertake on such a task, and the inherent difficulty of ... More
Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal modelsMar 12 2019Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as ... More
Are nuclei in stratified squamous epithelium high scattering or low scattering?Mar 10 2019Imaging nuclei of keratincoytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, ... More
Failing Fontan Cavopulmonary Support: A Modeling InvestigationMar 09 2019Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure ... More
Risks and Benefits of Using a Commercially Available Ventricular Assist Device for Failing Fontan Cavopulmonary Support: A Modeling InvestigationMar 09 2019Apr 18 2019Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure ... More
Controlled and Uncontrolled Stochastic Norton-Simon-Massagué Tumor Growth ModelsMar 08 2019Tumorigenesis is a complex process that is heterogeneous and affected by numerous sources of variability. This study presents a stochastic extension of a biologically grounded tumor growth model, referred to as the Norton-Simon-Massagu\'e (NSM) tumor ... More
Higher ventricular rate during atrial fibrillation relates to increased cerebral hypoperfusions and hypertensive eventsMar 08 2019Atrial fibrillation (AF) is associated with cognitive impairment/dementia, independently of clinical cerebrovascular events (stroke/TIA). One of the plausible mechanisms is the occurrence of AF-induced transient critical hemodynamic events; however, it ... More
Changing cell mechanics -- a precondition for malignant transformation of oral squamous carcinoma cellsMar 08 2019Oral squamous cell carcinomas (OSCC) are the 6th most common cancer and the diagnosis is often belated for a curative treatment. The reliable and early differentiation between healthy and diseased cells is the main aim of this study in order to improve ... More
Collective ECM remodeling organizes 3D collective cancer invasionMar 08 2019Tumor metastasis, traditionally considered as random spreading of individual cancer cells, has been shown to also involve coordinated collective invasion in the tissue space. Here we demonstrate experimentally and computationally that physical interactions ... More
Collective ECM remodeling organizes 3D collective cancer invasionMar 08 2019Apr 03 2019Tumor metastasis, traditionally considered as random spreading of individual cancer cells, has been shown to also involve coordinated collective invasion in the tissue space. Here we demonstrate experimentally and computationally that physical interactions ... More
Characterization of Posidonia Oceanica Seagrass Aerenchyma through Whole Slide Imaging: A Pilot StudyMar 07 2019Characterizing the tissue morphology and anatomy of seagrasses is essential to predicting their acoustic behavior. In this pilot study, we use histology techniques and whole slide imaging (WSI) to describe the composition and topology of the aerenchyma ... More
Characterization of Posidonia Oceanica Seagrass Aerenchyma through Whole Slide Imaging: A Pilot StudyMar 07 2019Mar 11 2019Characterizing the tissue morphology and anatomy of seagrasses is essential to predicting their acoustic behavior. In this pilot study, we use histology techniques and whole slide imaging (WSI) to describe the composition and topology of the aerenchyma ... More
Histo-blood group glycans in the context of personalized medicineMar 07 2019Background: A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood transfusions, but ... More
Quantitative MRI molecular imaging in the evaluation of early post mortem changes in muscles. A feasibility study on a pig phantomMar 06 2019Estimating early postmortem interval EPI is a difficult task in daily forensic activity due to limitations of accurate and reliable methods. The aim of the present work is to describe a novel approach in the estimation of EPI based on quantitative magnetic ... More
Multiscale population dynamics in reproductive biology: singular perturbation reduction in deterministic and stochastic modelsMar 04 2019In this study, we describe different modeling approaches for ovarian follicle population dynamics, based on either ordinary (ODE), partial (PDE) or stochastic (SDE) differential equations, and accounting for interactions between follicles. We put a special ... More
Active Fingering Instability in Tissue SpreadingMar 01 2019During the spreading of epithelial tissues, the advancing tissue front often develops fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven fluids suggests that epithelial fingers could arise from an interfacial ... More
Transparency guided ensemble convolutional neural networks for stratification of pseudoprogression and true progression of glioblastoma multiformFeb 26 2019Pseudoprogression (PsP) is an imitation of true tumor progression (TTP) in patients with glioblastoma multiform (GBM). Differentiating them is a challenging and time-consuming task for radiologists. Although deep neural networks can automatically diagnose ... More
Active wetting of epithelial tissuesFeb 24 2019Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear, ... More
Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksFeb 22 2019The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences ... More
Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksFeb 22 2019Apr 15 2019The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences ... More
A toxicology-informed, safer by design approach for the fabrication of transparent electrodes based on silver nanowiresFeb 21 2019Fabrication of silver nanowires (AgNWs) with fine and independent control of both the diameter (from 30 to 120 nm) and length (from 5 to 120 $\mu$m) by concomitant addition of co-nucleants and temperature control is demonstrated, and used for the preparation ... More
Activation of a muscle as a mapping of stress-strain curvesFeb 19 2019The mathematical modeling of the contraction of a muscle is a crucial problem in biomechanics. Several different models of muscle activation exist in literature. A possible approach to contractility is the so-called active strain: it is based on a multiplicative ... More
Afferent Fiber Activity-Induced Cytoplasmic Calcium Signaling in Parvalbumin-Positive Inhibitory Interneurons of the Spinal Cord Dorsal HornFeb 17 2019Neuronal calcium (Ca2+) signaling represents a molecular trigger for diverse central nervous system adaptations and maladaptions. The altered function of dorsal spinal inhibitory interneurons is strongly implicated in the mechanisms underlying central ... More
Atlas-based automated detection of swim bladder in Medaka embryoFeb 16 2019Fish embryo models are increasingly being used both for the assessment of chemicals efficacy and potential toxicity. This article proposes a methodology to automatically detect the swim bladder on 2D images of Medaka fish embryos seen either in dorsal ... More
A Spatial Filtering Approach to Biological PatterningFeb 08 2019Interactions between neighboring cells are essential for generating or refining patterns in a number of biological systems. We propose a discrete filtering approach to predict how networks of cells modulate spatially varying input signals to produce more ... More
New combinational therapies for cancer using modern statistical mechanicsFeb 02 2019We investigate a new dynamical system that describes tumor-host interaction. The equation that describes the untreated tumor growth is based on non-extensive statistical mechanics. Recently, this model has been shown to fit successfully exponential, Gompertz, ... More
Modeling the Mitral ValveJan 31 2019This work is concerned with modeling and simulation of the mitral valve, one of the four valves in the human heart. The valve is composed of leaflets, the free edges of which are supported by a system of chordae, which themselves are anchored to the papillary ... More
Chester: A Web Delivered Locally Computed Chest X-Ray Disease Prediction SystemJan 31 2019Deep learning has shown promise to augment radiologists and improve the standard of care globally. Two main issues that complicate deploying these systems are patient privacy and scaling to the global population. To deploy a system at scale with minimal ... More
A Revision of the Bernoulli Equation as a Controller of the Fick's Diffusion Equation in Drug Delivery ModelingJan 30 2019Mathematical equations can be used as effectual tools in drug delivery systems modeling and are also highly helpful to have a theoretical understanding of controlled drug release and diffusion mechanisms. In this study we aim to present a mathematical ... More
Steroid Receptors and Vertebrate EvolutionJan 28 2019Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, ... More
A Mechano-Chemical model for tumors growthJan 28 2019In this paper we present a study of local dynamics of the growth of cancer tumor and healthy cells considering the presence of nutrients in the system. We also analyze the evolution of system if we take indirectly into account the level of alkalinity ... More
Derivation and application of effective interface conditions for continuum mechanical models of cell invasion through thin membranesJan 18 2019Feb 02 2019We consider a continuum mechanical model of cell invasion through thin membranes, which consists of a transmission problem for a system of nonlinear partial differential equations for the cell volume fraction complemented with continuity of stresses and ... More
A Biomechanical Study on the Use of Curved Drilling Technique for Treatment of Osteonecrosis of Femoral HeadJan 14 2019Osteonecrosis occurs due to the loss of blood supply to the bone, leading to spontaneous death of the trabecular bone. Delayed treatment of the involved patients results in collapse of the femoral head, which leads to a need for total hip arthroplasty ... More
Why Pacing Frequency Affects the Production of Early Afterdepolarizations in Cardiomyocytes: An Explanation Revealed by Slow/Fast Analysis of a Minimal ModelJan 14 2019Early afterdepolarizations (EADs) are pathological voltage oscillations in cardiomyocytes that have been observed in response to a number of pharmacological agents and disease conditions. EADs are small voltage fluctuations that occur during the plateau ... More
Anatomy of the vertebral column lymphatic network in miceJan 12 2019Cranial lymphatic vessels (LVs) are involved in transport of fluids, macromolecules and CNS immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize ... More
A mathematical model of the effects of aging on naive T-cell population and diversityJan 02 2019The human adaptive immune response is known to weaken in advanced age, resulting in increased severity of pathogen-born illness, poor vaccine efficacy, and a higher prevalence of cancer in the elderly. Age-related erosion of the T-cell compartment has ... More
Microglial memory of early life stress, epigenetic mechanisms and susceptibility to neurodegeneration in adulthoodJan 01 2019In this review we present a concept that, despite mounting evidence, received little attention so far: susceptibility to adult neurodegenerative diseases may be programmed in utero and early postnatal preventive measures may reduce the risk. We delineate ... More
Mathematical models of cardiovascular control by the autonomic nervous systemDec 29 2018Jan 17 2019This PhD thesis develops an integrated mathematical model for autonomic nervous system control on cardiovascular activity. The model extensively covers cardiovascular neural pathways including a wide range of afferent sensory neurons, central processing ... More
Effect of cryopreservation on the structural and functional integrity of cell membranes of sugarcane (Saccharum sp.) embryogenic callusesDec 27 2018In this paper, we investigated if the differences consistently noted in survival and plantlet production between cryopreserved and non-cryopreserved, control sugarcane embryogenic calluses were related to modifications induced during cryopreservation ... More
Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems modelsDec 26 2018Heart transplant patients are followed for up to a year with periodic right heart catheterizations (RHCs) to identify post-transplant complications and guide treatment. Positive outcomes are associated with a steady reduction of right ventricular and ... More
Robust Approach for Rotor Mapping in Cardiac TissueDec 26 2018The motion of and interaction between phase singularities that anchor spiral waves captures many qualitative and, in some cases, quantitative features of complex dynamics in excitable systems. Being able to accurately reconstruct their position is thus ... More
Nanorobots-assisted Detection of Multifocal Cancer: A Multimodal Optimization PerspectiveDec 25 2018We propose a new framework of computing-inspired multifocal cancer detection procedure (MCDP). Under the rubric of MCDP, the tumor foci to be detected are regarded as solutions of the objective function, the tissue region around the cancer areas represents ... More
Piezoelectric Barium Titanate Nanostimulators for the Treatment of Glioblastoma MultiformeDec 19 2018Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer ... More
Stochastic Modelling and Dynamic Analysis of Cardiovascular System with Rotary Left Ventricular Assist DevicesDec 18 2018The left ventricular assist device (LVAD) has been used for end-stage heart failure patients as a therapeutic option. The aortic valve plays a critical role in heart failure and its treatment with LVAD. The cardiovascular-LVAD model is often used to investigate ... More
Using deceased-donor kidneys to initiate chains of living donor kidney paired donations: algorithms and experimentationDec 17 2018We design a flexible algorithm that exploits deceased donor kidneys to initiate chains of living donor kidney paired donations, combining deceased and living donor allocation mechanisms to improve the quantity and quality of kidney transplants. The advantages ... More
Bridging the gap between individual-based and continuum models of growing cell populationsDec 14 2018May 11 2019Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations that describe ... More
Bridging the gap between individual-based and continuum models of growing cell populationsDec 14 2018Dec 18 2018Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations that describe ... More
Towards Fast Biomechanical Modeling of Soft Tissue Using Neural NetworksDec 13 2018To date, the simulation of organ deformations for applications like therapy planning or image-guided interventions is calculated by solving the elastodynamics equations. While efficient solvers have been proposed for fast simulations, methods that are ... More
Enhancing Blood Glucose Prediction with Meal Absorption and Physical Exercise InformationDec 13 2018Objective: Numerous glucose prediction algorithm have been proposed to empower type 1 diabetes (T1D) management. Most of these algorithms only account for input such as glucose, insulin and carbohydrate, which limits their performance. Here, we present ... More
Heart rate variability monitoring identifies asymptomatic toddlers exposed to Zika virus during pregnancyDec 13 2018Although Zika virus (ZIKV) seems to be prominently neurotropic, there are some reports of involvement of other organs, particularly the heart. Of special concern are those children exposed prenatally to ZIKV and born with no microcephaly or other congenital ... More
Geometry of epithelial cells provides a robust method for image based inference of stress within tissuesDec 11 2018Cellular mechanics plays an important role in epithelial morphogenesis, a process wherein cells reshape and rearrange to produce tissue-scale deformations. However, the study of tissue-scale mechanics is impaired by the difficulty of direct measurement ... More
Detection of Proteoglycan Loss from Articular Cartilage using Brillouin Microscopy, with Applications to OsteoarthritisDec 06 2018The degeneration of articular cartilage (AC) occurs in osteoarthritis (OA), which is a leading cause of pain and disability in middle-aged and older people. The early disease related changes in cartilage extra-cellular matrix (ECM) start with depletion ... More
Collective stresses drive competition between monolayers of normal and Ras-transformed cellsDec 04 2018We study the competition for space between two cell lines that differ only in the expression of the Ras oncogene. The two cell populations are initially separated and set to migrate antagonistically towards an in-between stripe of free substrate. After ... More
Optical probe pressure effects on cutaneous blood flowNov 28 2018The variation of blood flow characteristics caused by the probe pressure during noninvasive studies is of particular interest within the context of fundamental and applied research. It has been shown previously that the weak local pressure induces vasodilation, ... More
Modeling the respiratory Central Pattern Generator with resonate-and-fire Izhikevich-NeuronsNov 28 2018Computational models of the respiratory central pattern generator (rCPG) are usually based on biologically-plausible Hodgkin Huxley neuron models. Such models require numerous parameters and thus are prone to overfitting. The HH approach is motivated ... More
Nanoscale topography and poroelastic properties of model tissue breast gland basement membranesNov 27 2018Basement membranes (BMs) are thin layers of condensed extracellular matrix proteins serving as permeability filters, cellular anchoring sites, and barriers against cancer cell invasion. It is believed that their biomechanical properties play a crucial ... More
Maintaining the stem cell niche in multicellular models of epitheliaNov 27 2018The maintenance of a stem cell niche in epithelial tissues is critical for healthy function. In this paper we investigate how current modelling methods can result in erroneous loss of stem cells from the stem cell niche. Using an established model of ... More
Review of studies in field of the effects of nanotechnology on breast cancerNov 20 2018Cancer is the main cause of mortality at the developed countries and is the second cause of mortality at the developing countries and breast cancer is the most prevalent malignancy and the first cause of mortality among women of the world. At the US, ... More
Comprehensive study on influence of low dose chronic consumption of silver nanoparticles on cognitive functions and identification of the effect reasonsNov 20 2018The influence of the daily prolonged administration of silver nanoparticles on cognitive functions of model mammals was studied. The accumulation of silver in whole brain, hippocampus, cerebellum, cortex and residual part of mice brain was investigated ... More
Ferrimagnetic organelles in multicellular organismsNov 16 2018In this paper, it was revealed by means of methods of atomic force microscopy and magnetic force microscopy that the biogenic magnetic nanoparticles are localized in the form of chains in the walls of the capillaries of animals and the walls of the conducting ... More
Extra-cellular matrix rigidity may dictate the fate of injury outcomeNov 12 2018Mar 03 2019After injury, if regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after injury. We explore ... More
Functional change in children with cerebral palsyNov 09 2018Introduction There is increasing focus on the association between trunk control and functional abilities in children with cerebral palsy (CP). The purpose of this study was to determine the extent of functional change in children with CP who participated ... More