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Where did the tumor start? An inverse solver with sparse localization for tumor growth modelsJul 15 2019We present a numerical scheme for solving an inverse problem for parameter estimation in tumor growth models for glioblastomas, a form of aggressive primary brain tumor. The growth model is a reaction-diffusion partial differential equation (PDE) for ... More
Complexity of Brain TumorsJul 13 2019Jul 17 2019Tumor growth is a complex process characterized by uncontrolled cell proliferation and invasion of neighboring tissues. The understanding of these phenomena is of vital importance to establish appropriate diagnosis and therapeutic strategy and starts ... More
Complexity of Brain TumorsJul 13 2019Tumor growth is a complex process characterized by uncontrolled cell proliferation and invasion of neighboring tissues. The understanding of these phenomena is of vital importance to establish appropriate diagnosis and therapeutic strategy and starts ... More
retina-VAE: Variationally Decoding the Spectrum of Macular DiseaseJul 11 2019In this paper, we seek a clinically-relevant latent code for representing the spectrum of macular disease. Towards this end, we construct retina-VAE, a variational autoencoder-based model that accepts a patient profile vector (pVec) as input. The pVec ... More
A tractable mathematical model for tissue growthJul 11 2019Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed interface evolving ... More
A structured population model of clonal selection in acute leukemias with multiple maturation stagesJul 05 2019Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain unclear. In this paper, we present a multi-compartmental continuously structured ... More
Systems biology approach to the origin of the tetrapod limbJul 05 2019It is still not understood how similar genomic sequences have generated diverse and spectacular forms during evolution. The difficulty to bridge phenotypes and genotypes stems from the complexity of multicellular systems, where thousands of genes and ... More
An Atomistic First-Principles Density Functional Theory Model for Single Layer Dry \textit{Stratum Corneum}Jul 04 2019Many questions concerning the biophysical and physiological properties of skin are still open. Skin aging, permeability, dermal absorption, hydration and drug transdermal delivery, are few examples of processes with its underlying mechanisms unveiled. ... More
One-Way Coupled Tumor Response Model for Combined-Hyperthermia-Radiotherapy Treatment with Anisotropic ScatteringJul 03 2019Therapies such as combined-hyperthermia-radiotherapy (CHR) take advantage of excellent radiosensitization properties of hyperthermia and treat of tumors with both radiation and heat. To appropriately model a CHR treatment, features like tumor heating ... More
Cell-scale degradation of peritumoural extracellular matrix fibre network and its role within tissue-scale cancer invasionJul 02 2019Local cancer invasion of tissue is a complex, multiscale process which plays an essential role in tumour progression. Occurring over many different temporal and spatial scales, the first stage of invasion is the secretion of matrix degrading enzymes (MDEs) ... More
Multiscale dynamics of a heterotypic cancer cell population within a fibrous extracellular matrixJul 01 2019Local cancer cell invasion is a complex process involving many cellular and tissue interactions and is an important prerequisite for metastatic spread, the main cause of cancer related deaths. Occurring over many different temporal and spatial scales, ... More
Dual Role of Cell-Cell Adhesion In Tumor Suppression and ProliferationJun 26 2019Jul 10 2019It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion strength, local cell density and force fluctuations in regulating cell proliferation ... More
Dual Role of Cell-Cell Adhesion In Tumor Suppression and ProliferationJun 26 2019It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion strength, local cell density and force fluctuations in regulating cell proliferation ... More
Intrinsic noise, Delta-Notch signalling and delayed reactions promote sustained, coherent, synchronised oscillations in the presomitic mesodermJun 21 2019Using a stochastic individual-based modelling approach, we examine the role that Delta-Notch signalling plays in the regulation of a robust and reliable somite segmentation clock. We find that not only can Delta-Notch signalling synchronise noisy cycles ... More
Towards a consensus on rheological models for shear waves in soft tissuesJun 20 2019A rising wave of technologies and instruments are enabling more labs and clinics to make a variety of measurements related to tissue viscoelastic properties. These instruments include elastography imaging scanners, rheological shear viscometers, and a ... More
Automated Definition of Skeletal Disease Burden in Metastatic Prostate Carcinoma: a 3D analysis of SPECT/CT imagesJun 19 2019To meet the current need for skeletal tumor-load estimation in prostate cancer (mCRPC), we developed a novel approach, based on adaptive bone segmentation. In this study, we compared the program output with existing estimates and with the radiological ... More
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's DiseaseJun 18 2019Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic ... More
How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributionsJun 18 2019The set of T cells that express the same T cell receptor (TCR) sequence represent a T cell clone. The number of different naive T cell clones in an organism reflects the number of different T cell receptors (TCRs) arising from recombination of the V(D)J ... More
Multiscale Nakagami parametric imaging for improved liver tumor localizationJun 11 2019Effective ultrasound tissue characterization is usually hindered by complex tissue structures. The interlacing of speckle patterns complicates the correct estimation of backscatter distribution parameters. Nakagami parametric imaging based on localized ... More
Reinforcement Learning-Based Adaptive Insulin Advisor for Individuals with Type 1 Diabetes Patients under Multiple Daily Injections TherapyJun 07 2019The existing adaptive basal-bolus advisor (ABBA) was further developed to benefit patients under insulin therapy with multiple daily injections (MDI). Three different in silico experiments were conducted with the DMMS.R simulator to validate the approach ... More
Femoral fracture load and damage localisation pattern prediction based on a quasi-brittle law : linear and non-linear FE meshingJun 07 2019Finite element analysis is one of the most used tool for studying femoral neck fracture. Nerveless, consensus concerning either the choice of material characteristics, damage law and /or geometric models (linear on nonlinear) still remains unreached. ... More
Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to CureJun 06 2019Jun 16 2019We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin ... More
#neverforget - Photobiomodulation Against Alzheimer's Disease: A Systematic ReviewJun 06 2019Alzheimer's disease affects an ever-increasing number of people in the aging population. Current treatment options are limited to a narrow time frame at the mild to moderate stage of dementia, and patients are confronted with the inevitable progression ... More
Influence of Initial Residual Stress on Growth and Pattern Creation for a Layered AortaJun 03 2019Residual stress is ubiquitous and indispensable in most biological and artificial materials, where it sustains and optimizes many biological and functional mechanisms. The theory of volume growth, starting from a stress-free initial state, is widely used ... More
Immunopathogenesis in Psoriasis through a Density-type Mathematical ModelJun 03 2019Disease psoriasis occurs as chronic inflammation of skin and appears as scaly red lesions on skin surface. Advent of several immunosuppressive drugs established that the disease stems from immuno-pathogenic disorder in human blood. Cell biological as ... More
Dynamics of T Cell Receptor Distributions Following Acute Thymic Atrophy and ResumptionMay 29 2019Naive human T cells are produced in the thymus, which atrophies abruptly and severely in response to physical or psychological stress. To understand how an instance of stress affects the size and "diversity" of the peripheral naive T cell pool, we derive ... More
Real-time Cellular Impedance Monitoring and Imaging of Biological Barriers in a dual flow membrane bioreactorMay 27 2019The generation of physiologically relevant in-vitro models of biological barriers can play a key role in understanding human diseases and in the development of more predictive methods for assessing toxicity and drug or nutrient absorption. Here, we present ... More
Simple Muscle Architecture Analysis (SMA): an ImageJ macro tool to automate measurements in B-mode ultrasound scansMay 23 2019In vivo measurements of muscle architecture (i.e. the spatial arrangement of muscle fascicles) are routinely included in research and clinical settings to monitor muscle structure, function and plasticity. However, in most cases such measurements are ... More
Simple Muscle Architecture Analysis (SMA): an ImageJ macro tool to automate measurements in B-mode ultrasound scansMay 23 2019May 31 2019In vivo measurements of muscle architecture (i.e. the spatial arrangement of muscle fascicles) are routinely included in research and clinical settings to monitor muscle structure, function and plasticity. However, in most cases such measurements are ... More
Automating Whole Brain Histology to MRI Registration: Implementation of a Computational PipelineMay 22 2019Although the latest advances in MRI technology have allowed the acquisition of higher resolution images, reliable delineation of cytoarchitectural or subcortical nuclei boundaries is not possible. As a result, histological images are still required to ... More
Physical Models of Collective Cell MigrationMay 19 2019Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalogue of the cell-cell ... More
A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratioMay 16 2019Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a mechanism ... More
A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratioMay 16 2019May 21 2019Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a mechanism ... More
Anomalous Advection-Diffusion Models for Avascular Tumour GrowthMay 14 2019In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour spheroid. This understanding ... More
Towards a Multiphysics Model for Tumor Response to Combined-Hyperthermia-Radiotherapy TreatmentMay 10 2019Jul 03 2019We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall ... More
Towards a Multiphysics Model for Tumor Response to Combined-Hyperthermia-Radiotherapy TreatmentMay 10 2019We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of the overall ... More
Dynamical stability analysis of tumor growth and invasion: A reaction-diffusion modelMay 10 2019The acid-mediated tumor invasion hypothesis proposes that altered glucose metabolism exhibited by the vast majority of tumors leads to increased acid (H+ ion) production which subsequently facilitates tumor invasion [1-3]. The reaction-diffusion model ... More
Supervised machine learning based multi-task artificial intelligence classification of retinopathiesMay 10 2019Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly ... More
Surface tension controls the onset of gyrification in brain organoidsMay 09 2019Understanding the mechanics of brain embryogenesis can provide insights on pathologies related to brain development, such as lissencephaly, a genetic disease which cause a reduction of the number of cerebral sulci. Recent experiments on brain organoids ... More
Comparative approaches to understanding thyroid hormone regulation of neurogenesisMay 09 2019Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development, increasing ... More
Mechanical heterogeneity in tissues promotes rigidity and controls cellular invasionMay 07 2019We study the influence of cell-level mechanical heterogeneity in epithelial tissues using a vertex-based model. Heterogeneity in single cell stiffness is introduced as a quenched random variable in the preferred shape index($p_0$) for each cell. We uncovered ... More
Tuning the Transdermal Transport by Application of External Continuous Electric Field: A Molecular Dynamics Coarse-Grained StudyMay 06 2019Since a long time the application of small electric potentials on biological membranes (iontophoresis) proved enabling control and improvement of transdermal delivery of substances across this barrier. In spite of a large experimental data, the detailed ... More
Machine Learning to Predict Developmental Neurotoxicity with High-throughput Data from 2D Bio-engineered TissuesMay 06 2019There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from ... More
Glassy Dynamics in Models of Confluent Tissue with Mitosis and ApoptosisMay 05 2019Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy dynamics in ... More
Paper-based cell cryopreservationMay 02 2019The continuous development of simple and practical cell cryopreservation methods is of great importance to a variety of sectors, especially when considering the efficient short- and long-term storage of cells and their transportation. Although the overall ... More
An orthotropic electro-viscoelastic model for the heart with stress-assisted diffusionMay 01 2019May 20 2019We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law (this is so for ... More
An orthotropic electro-viscoelastic model for the heart with stress-assisted diffusionMay 01 2019We propose and analyse the properties of a new class of models for the electromechanics of the cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law (this is so ... More
Energy Balance in Cell Phone Radiofrequency Radiation Exposed Mice and RatsApr 29 2019The National Toxicology Program exposed mice and rats to cell phone radiofrequency radiation. They observer cancers in male rats but not in male mice and different increases in body temperature between mice and rats using identical frequency and intensity ... More
A mechanism for sarcomere breathing: volume changes and advective flow within the myofilament latticeApr 29 2019During muscle contraction, myosin motors anchored on thick filaments bind to and slide actin thin filaments. These motors rely on ATP, supplied at the limits of diffusion from the sarcoplasm to the interior of the lattice of actin and myosin. Classic ... More
Voluntary phantom hand and finger movements in transhumeral amputees could be used to naturally control polydigital prosthesesApr 26 2019An arm amputation is extremely invalidating since many of our daily tasks require bi-manual and precise control of hand movements. Perfect hand prostheses should therefore offer a natural, intuitive and cognitively simple control over their numerous biomimetic ... More
Can fallopian tube anatomy predict pregnancy and pregnancy outcomes after tubal reversal surgery?Apr 21 2019We conducted this study to determine if postoperative fallopian tube anatomy can predict the likelihood of pregnancy and pregnancy outcomes after tubal sterilisation reversal. We built a flexible, non-parametric, multivariate model via generalised additive ... More
Quantification of Nematic Cell Polarity in Three-dimensional TissuesApr 18 2019How epithelial cells coordinate their polarity to form complex tissues and organs remains a fundamental question in biology. Here, we characterize a unique type of polarity found in liver tissue - nematic cell polarity, which is different from the common ... More
Impaired coronary blood flow at higher heart rates during atrial fibrillation: investigation via multiscale modellingApr 16 2019Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the present work ... More
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary reportApr 12 2019Jul 17 2019Psychosocial stress during pregnancy is a known contributor to preterm birth, but also has been increasingly appreciated as an in utero insult acting long-term on prenatal and postnatal neurodevelopmental trajectories. These events impact many information ... More
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary reportApr 12 2019Psychosocial stress during pregnancy is a known contributor to preterm birth, but also has been increasingly appreciated as an in utero insult acting long-term on prenatal and postnatal neurodevelopmental trajectories. These events impact many information ... More
Interpretable Classification from Skin Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter StudyApr 12 2019For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep convolutional neural networks ... More
DNN-based Acoustic-to-Articulatory Inversion using Ultrasound Tongue ImagingApr 12 2019Speech sounds are produced as the coordinated movement of the speaking organs. There are several available methods to model the relation of articulatory movements and the resulting speech signal. The reverse problem is often called as acoustic-to-articulatory ... More
Conformational catalysis of cataract-associated aggregation by interacting intermediates in a human eye lens crystallinApr 07 2019Most known proteins in nature consist of multiple domains. Interactions between domains may lead to unexpected folding and misfolding phenomena. This study of human {\gamma}D-crystallin, a two-domain protein in the eye lens, revealed one such surprise: ... More
Electric-induced reversal of morphogenesis in Hydra regenerationApr 07 2019Morphogenesis in whole-body regeneration requires the dynamic interplay of three types of processes: biochemical, mechanical and electrical, which span all scales from the molecular to the entire organism. Despite significant progress in elucidating the ... More
Cell damage and mitigation in Swiss albino mice: experiment and modellingApr 05 2019Chronic exposure to inorganic arsenic is a potential cause of carcinogenesis. It elicits its potential by generation of ROS, leading to DNA, protein and lipid damage. Therefore, the deleterious effect of arsenic can be mitigated by quenching ROS using ... More
Respiratory sympathetic modulation is augmented in chronic kidney diseaseApr 03 2019Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions ... More
Passive Cervical Spine Ligaments Provide Stability during Head Impacts in VivoApr 02 2019It has long been suggested that neck muscle strength and anticipatory cocontraction can decrease head motions during head impacts. Here, we quantify the relative angular impulse contributions of neck soft tissue to head stabilization using a musculoskeletal ... More
Alternative Scoring Method of Pleurisy in Slaughtered Pigs: Preliminary InvestigationsApr 02 2019The slaughterhouse is very useful in monitoring the health status of livestock, the profitability of their breeding and the effectiveness of therapeutic and/or prophylactic strategies. Over the years, a number of methods have been developed to quantify ... More
Quantitative phase microscopy spatial signatures of cancer cellsApr 02 2019We present cytometric classification of live healthy and cancer cells by using the spatial morphological and textural information found in the label-free quantitative phase images of the cells. We compare both healthy cells to primary tumor cell and primary ... More
The Configuration of the Perivascular System Transporting Macromolecules in the CNS (PREPRINT)Apr 02 2019Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space. Solutes and particles can translocate along these perivascular conduits, reportedly ... More
A Deterministic Method to Calculate the AIS Trauma Score from a Finite Element Organ Trauma Model (OTM)Apr 01 2019Traumatic injuries are measured using the Abbreviated Injury Scale (AIS), which is a risk to life scale. New human computer models use stresses and strains to evaluate whether serious or fatal injuries are reached, unfortunately these tensors bear no ... More
Overt and covert paths for sound in the auditory system of mammalsMar 28 2019Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we propose a bioelectronic ... More
Deciphering the underlying mechanisms of the pharyngeal motions in Caenorhabditis elegansMar 28 2019The pharynx of the nematode Caenorhabditis elegans is a neuromuscular pump that exhibits two typical motions: pumping and peristalsis. While the dynamics of these motions are well characterized, the underlying mechanisms generating most of them are not ... More
Effect of MTU length on child-adult difference in neuromuscular fatigueMar 27 2019Purpose The purpose of this study was to compare the development and etiology of neuromuscular fatigue of the knee extensor muscles (KE) at different muscle-tendon unit (MTU) lengths during repeated maximal voluntary isometric contractions (MVIC) between ... More
Single-cell approaches to cell competition: high-throughput imaging, machine learning and simulationsMar 25 2019Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been identified in many physiological and pathological contexts, driven either by ... More
A quantitative study on the role of TKI combined with Wnt/$β$-catenin signaling and IFN-$α$ in the treatment of CML through deterministic and stochastic approachesMar 22 2019We propose deterministic and stochastic models for studying the pharmacokinetics of chronic myeloid leukemia (CML), upon administration of IFN-$\alpha$ (the traditional treatment for CML), TKI (the current frontline medication for CML) and Wnt/$\beta$-catenin ... More
A quantitative study on the role of TKI combined with Wnt/$β$-catenin signaling and IFN-$α$ in the treatment of CML through deterministic and stochastic approachesMar 22 2019Jun 05 2019We propose deterministic and stochastic models for studying the pharmacokinetics of chronic myeloid leukemia (CML), upon administration of IFN-$\alpha$ (the traditional treatment for CML), TKI (the current frontline medication for CML) and Wnt/$\beta$-catenin ... More
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine IL-6 are related to synovitis and pain in end-stage knee osteoarthritis patientsMar 20 2019Little is known about local and systemic biomarkers in relation to synovitis and pain in end-stage osteoarthritis (OA) patients. We investigated the associations between the novel extracellular matrix biomarker, C1M, and local and systemic interleukin ... More
From individual-based mechanical models of multicellular systems to free-boundary problemsMar 15 2019In this paper we present an individual-based mechanical model that describes the dynamics of two contiguous cell populations with different proliferative and mechanical characteristics. An off-lattice modelling approach is considered whereby: (i) every ... More
Interkinetic nuclear migration in the zebrafish retina as a diffusive processMar 13 2019A major hallmark of neural development is the oscillatory movement of nuclei between the apical and basal surfaces of the neuroepithelium during the process of interkinetic nuclear migration (IKNM). Here, we employ long-term, rapid lightsheet and two-photon ... More
Towards Unsupervised Cancer Subtyping: Predicting Prognosis Using A Histologic Visual DictionaryMar 12 2019Unlike common cancers, such as those of the prostate and breast, tumor grading in rare cancers is difficult and largely undefined because of small sample sizes, the sheer volume of time needed to undertake on such a task, and the inherent difficulty of ... More
Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal modelsMar 12 2019Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as ... More
Are nuclei in stratified squamous epithelium high scattering or low scattering?Mar 10 2019Imaging nuclei of keratincoytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, ... More
Contrast of nuclei in stratified squamous epithelium in optical coherence tomography images at 800 nmMar 10 2019Jun 03 2019Imaging nuclei of keratinocytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, ... More
Failing Fontan Cavopulmonary Support: A Modeling InvestigationMar 09 2019Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure ... More
Risks and Benefits of Using a Commercially Available Ventricular Assist Device for Failing Fontan Cavopulmonary Support: A Modeling InvestigationMar 09 2019Apr 18 2019Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure ... More
Controlled and Uncontrolled Stochastic Norton-Simon-Massagué Tumor Growth ModelsMar 08 2019Tumorigenesis is a complex process that is heterogeneous and affected by numerous sources of variability. This study presents a stochastic extension of a biologically grounded tumor growth model, referred to as the Norton-Simon-Massagu\'e (NSM) tumor ... More
Higher ventricular rate during atrial fibrillation relates to increased cerebral hypoperfusions and hypertensive eventsMar 08 2019Atrial fibrillation (AF) is associated with cognitive impairment/dementia, independently of clinical cerebrovascular events (stroke/TIA). One of the plausible mechanisms is the occurrence of AF-induced transient critical hemodynamic events; however, it ... More
Changing cell mechanics -- a precondition for malignant transformation of oral squamous carcinoma cellsMar 08 2019Oral squamous cell carcinomas (OSCC) are the 6th most common cancer and the diagnosis is often belated for a curative treatment. The reliable and early differentiation between healthy and diseased cells is the main aim of this study in order to improve ... More
Collective ECM remodeling organizes 3D collective cancer invasionMar 08 2019Tumor metastasis, traditionally considered as random spreading of individual cancer cells, has been shown to also involve coordinated collective invasion in the tissue space. Here we demonstrate experimentally and computationally that physical interactions ... More
Collective ECM remodeling organizes 3D collective cancer invasionMar 08 2019Apr 03 2019Tumor metastasis, traditionally considered as random spreading of individual cancer cells, has been shown to also involve coordinated collective invasion in the tissue space. Here we demonstrate experimentally and computationally that physical interactions ... More
Characterization of Posidonia Oceanica Seagrass Aerenchyma through Whole Slide Imaging: A Pilot StudyMar 07 2019Characterizing the tissue morphology and anatomy of seagrasses is essential to predicting their acoustic behavior. In this pilot study, we use histology techniques and whole slide imaging (WSI) to describe the composition and topology of the aerenchyma ... More
Characterization of Posidonia Oceanica Seagrass Aerenchyma through Whole Slide Imaging: A Pilot StudyMar 07 2019Mar 11 2019Characterizing the tissue morphology and anatomy of seagrasses is essential to predicting their acoustic behavior. In this pilot study, we use histology techniques and whole slide imaging (WSI) to describe the composition and topology of the aerenchyma ... More
Histo-blood group glycans in the context of personalized medicineMar 07 2019Background: A subset of histo-blood group antigens including ABO and Lewis are oligosaccharide structures which may be conjugated to lipids or proteins. They are known to be important recognition motifs not only in the context of blood transfusions, but ... More
Quantitative MRI molecular imaging in the evaluation of early post mortem changes in muscles. A feasibility study on a pig phantomMar 06 2019Estimating early postmortem interval EPI is a difficult task in daily forensic activity due to limitations of accurate and reliable methods. The aim of the present work is to describe a novel approach in the estimation of EPI based on quantitative magnetic ... More
Multiscale population dynamics in reproductive biology: singular perturbation reduction in deterministic and stochastic modelsMar 04 2019In this study, we describe different modeling approaches for ovarian follicle population dynamics, based on either ordinary (ODE), partial (PDE) or stochastic (SDE) differential equations, and accounting for interactions between follicles. We put a special ... More
Active Fingering Instability in Tissue SpreadingMar 01 2019During the spreading of epithelial tissues, the advancing tissue front often develops fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven fluids suggests that epithelial fingers could arise from an interfacial ... More
Transparency guided ensemble convolutional neural networks for stratification of pseudoprogression and true progression of glioblastoma multiformFeb 26 2019Pseudoprogression (PsP) is an imitation of true tumor progression (TTP) in patients with glioblastoma multiform (GBM). Differentiating them is a challenging and time-consuming task for radiologists. Although deep neural networks can automatically diagnose ... More
Active wetting of epithelial tissuesFeb 24 2019Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear, ... More
Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksFeb 22 2019The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences ... More
Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksFeb 22 2019Apr 15 2019The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences ... More
Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksFeb 22 2019May 21 2019The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences ... More
A toxicology-informed, safer by design approach for the fabrication of transparent electrodes based on silver nanowiresFeb 21 2019Fabrication of silver nanowires (AgNWs) with fine and independent control of both the diameter (from 30 to 120 nm) and length (from 5 to 120 $\mu$m) by concomitant addition of co-nucleants and temperature control is demonstrated, and used for the preparation ... More
Holocrine Secretion and Kino Flow in Angiosperms: Their Role and Physiological Advantages in Plant Defence MechanismsFeb 20 2019Kinos are plant exudates, rich in polyphenols, produced by several angiosperms in reaction to damage. They flow out of kino veins, schizolysigenous ducts composing an anatomically distinct continuous system of tangentially anastomosing lacunae produced ... More
Activation of a muscle as a mapping of stress-strain curvesFeb 19 2019The mathematical modeling of the contraction of a muscle is a crucial problem in biomechanics. Several different models of muscle activation exist in literature. A possible approach to contractility is the so-called active strain: it is based on a multiplicative ... More